You should not receive a sodium hyaluronate injection if you have an infection in your knee or in the skin around your knee. Sodium hyaluronate injection update horizon blue cross blue. About hyaluronate injections in your knee memorial sloan. Effectiveness of intraarticular injections of sodium. Brand names are cystistat, ophthalin, orthovisc, supartz. The healon ophthalmic viscosurgical device ovd is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Sodium hyaluronate is the sodium salt of hyaluronic acid. Ibm micromedex for the first 48 hours after you receive this medicine, avoid strenuous activities or prolonged more than 1 hour activities that put a lot of weight on your legs, such as jogging, heavy lifting, playing tennis, or standing on your feet for a long period of time. Hyaluronic acid injections for osteoarthritis are offered for the relief of joint pain but are not considered to be effective inosteoarthritis, particularly of the knee. The drug is also used osteoarthritis as a replacement for synovial fluid and to treat some forms of cystitis. Sodium hyaluronate is a watersoluble salt form of hyaluronic acid created by scientists to increase stability and lessen the likelihood of oxidization. Pdf management of tennis elbow with sodium hyaluronate. Today, ha usually labeled as sodium hyaluronate or hyaluronic acid is also an ingredient in a number of overthecounter oral preparations. This fluid acts as a lubricant and shock absorber for the joints.
Nov 14, 2015 men or women over 40 years of age with documented knee osteoarthritis and womac subscore a severity of pain. Find patient medical information for sodium hyaluronate oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hyaluronate is the same as a natural substance that is found in your body. Sodium hyaluronate nl nl nl nl nl nl nl 9067327 nl not listed. Irritation where gelone hyaluronate and derivatives injection knee is used. Sodium hyaluronate of lower molecular weights has an inci name hydrolyzed hyaluronic acid. It can bind to specific receptors for which it has a high affinity the polyanionic form, commonly referred to as hyaluronan, is a viscoelastic polymer found in the aqueous and vitreous humour of the eye and in the.
Viscosupplementation with intraarticular sodium hyaluronate offers another approach to the treatment by addressing the degradation of hyaluronic acid ha in the synovial fluid by the. Sodium hyaluronate and its derivatives form a viscoelastic solution in water suitable for aqueous and vitreous humor in ophthalmic surgery. Efficacy and safety of single injection of crosslinked. It is widely accepted that injection directly into the joint pouch enhances the healing of inflamed synovium by restoring lubrication of the joint fluid. Nov 09, 2018 sodium hyaluronate is similar to the fluid that surrounds your joints. We present this in order that the patient with osteoarthritis of the knee. It works by forming a protective layer over the affected area. This fluid acts as a lubricant and shock absorber for the joints sodium hyaluronate is used to treat knee pain caused by osteoarthritis sodium hyaluronate is usually given when other arthritis medications have not been effective sodium hyaluronate may also be used for purposes not listed in this medication. May 26, 2017 this randomized, doubleblind, multicenter, noninferiority trial was conducted to assess the efficacy and safety of a crosslinked hyaluronate xlha, single injection form compared with a linear high molecular hyaluronate hmwha, thrice injection form in patients with symptomatic knee osteoarthritis. Intraarticular injections of hyaluronan also known as sodium hyaluronate act as lubricants to restore elasticity and viscosity to the arthritic knee.
Sodium hyaluronate has a smaller molecular size than hyaluronic acid. Intraarticular hyaluronan injections are considered investigational for all other joints. Treatment of pain in osteoarthritis in knee in patients who have failed nonpharmacologic treatment and simple analgesics euflexxa, gelone, hyalgan, orthovisc, supartz, synvisc, synviscone or nonsteroidal antiinflammatory drugs nsaids. Hylartin v is a sterile pyrogenfree solution of a highly purified, specific fraction of the sodium salt of hyaluronic acid extracted from rooster combs. Sodium hyaluronate is a polysaccharide containing repeating disaccharide units of glucuronic acid and nacetylglucosamine. Nov 09, 2018 sodium hyaluronate is injected directly into your knee joint. At the third month, if the score for overall pain is still 40 mm on the vas, a second injection of adant can be given irrespective of which treatment was received previously. You can have both molecules in a wide range of molecular weights theoretically. Intra articular hyaluronan injections for treatment of osteoarthritis of the knee.
Sodium hyaluronate may also be used for purposes not listed in this medication guide. Description euflexxa is a viscoelastic, sterile solution of highly purified, high molecular weight 2. Sodium hyaluronate side effects, dosage, interactions. Description gelone is a sterile, transparent, and viscoelastic hydrogel composed of crosslinked hyaluronate, a derivative of highly purified sodium hyaluronate hyaluronan extracted from chicken.
The pain relief from hyaluronate injections may last from several weeks to a few months. Euflexxa is a very highly purified product extracted. We support specialty treatments and take a handson approach to patient care that makes a meaningful imprint on the health and quality of life of each patient. Treatment with hyaluronic acid gel preparations to improve the skins contour andor reduce depressions due to acne, scars, injury or wrinkles is considered cosmetic and is therefore excluded from coverage. The following is the procedure that has been used in the office of thomas haverbush, m. Us6949525b2 use of a mixture of sodium hyaluronate and. Safety of intraarticular hyaluronates for pain associated with osteoarthritis of the knee.
Supartz sodium hyaluronate supartz is a solution of hyaluronate, a natural substance that acts like oil to cushion and lubricate your knee joint. Optum specialty is a truly patientcentric specialty pharmacy. If the injection is done in slightly the wrong place, it wont damage your skin or muscle. Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis. Pharmacy medical policy injections for osteoarthritis table of contents. Hyaluronate sodium injection route side effects mayo clinic. Hyaluronan injections have very few sideeffects, although some people have a slight allergic reaction, which causes temporary pain and swelling in their joint after the injection. How to use sodium hyaluronate 10 mgml intraarticular syringe viscoelastics. Sodium hyaluronate, sodium hyaluronate manufacturers. Sodium hyaluronate is injected directly into your knee joint. Stanford chemicals company 72 fairbanks, suite 100, irvine, ca 92618, usa tel. The sodium hyaluronate is extracted from rooster combs.
Biologicals for sodium hyaluronate, orthovisc and you are directed to j7324. Hyaluronic acid derivatives durolane, euflexxa, gelsyn3. Intraarticular hyaluronate injection for knee osteoarthritis. The cegaba activity as a promoter of cell growth has been demonstrated in several studies carried out first by curti and fussi, and later by g. There was a dose injected in each knee so two units are reported. Us6949525b2 us10469,258 us46925803a us6949525b2 us 6949525 b2 us6949525 b2 us 6949525b2 us 46925803 a us46925803 a us 46925803a us 6949525 b2 us6949525 b2 us 6949525b2 authority us united states prior art keywords composition chondroitin sulfate method sodium hyaluronate joint prior art date 200111 legal status the legal status is an assumption. Teae, by preferred term, was injection site joint pain 2 1. Trade name sodium hyaluronate 1% solution inci name water and sodium hyaluronate 1. Most current pharmacological options are limited to alleviating pain and improving function. Sodium hyaluronate is usually given when other arthritis medications have not been effective. Verification of j7324 indicates it is a per dose code. Hyaluronate is similar to a substance that occurs naturally in joints and that helps joints work properly by acting like a lubricant and shock absorber.
Sodium hyaluronate injection update effective january 1, 2018, horizon bcbsnj will change the way that we approve and consider claims for certain sodium hyaluronate injections as noted below. Hyaluronate sodium injection route national library of. Food and drug administration fda labeled indications. Recently, ha receptors have been found on liver endothelial cells that play an important role in ha catabolism. Lupin launches hyalgan osteoarthritis injectable in india. Chemical product and company identification supplier. Each injection is administered once a week on the same day. Sodium hyaluronate is usually given once every week for 3 to 5 weeks. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Protects sking against friction and abrassion in the management of wounds and ulcers.
An independent licensee of the blue cross and blue shield association. Clinical trial of intraarticular injection of sodium hyaluronate in. This medicine is injected directly into the knee to relieve pain caused by osteoarthritis. Some effects of injection of hyaluronidase into the anterior chamber. These side effects may go away during treatment as your body adjusts to the medicine. Hyaluronidase and sodium hyaluronate in cataract surgery.
The effect of sodium hyaluronatechondroitin sulfate combined solution on cartilage formation in osteochondral defects of the rabbit knee. Sodium hyaluronate effects on pain and physical functioning in osteoarthritis of the knee. Sodium hyaluronate is similar to the fluid that surrounds the joints in your body. Intraarticular injections of sodium hyaluronate are proven andor medically necessary for treating pain due to osteoarthritis oa of the knee when administered according to u. A healthcare provider will give you this injection. Thus, while the halflife of unmodified ha sodium hyaluronate is on the order of 1 day, the halflife of crosslinked hylans i. Sodium hyaluronate in cataract and intraocular lens surgery. The greater manchester medicines management group gmmmg have also assessed sodium hyaluronate injection against the gmmmg wide do not prescribe list criteria and the group concluded that sodium hyaluronate products used for injection into the knee for the relief of osteoarthritis should be included in the gmmmg do not prescribe list. Each 1 ml of supartz contains 10 mg of sodium hyaluronate dissolved in physiological saline 1. May 26, 2015 hyaluronate molecules are long chains which form a filter network interspersed with normal cellular fluids. The sodium hyaluronate is derived from bacterial fermentation.
Intraarticular hyaluronan injections for osteoarthritis. Sodium hyaluronate of defined molecular size for treating. Federal law restricts this device to sale by or on the order of a physician or properly licensed practitioner. Durolane, euflexxa, gelone sodium hyaluronate injection. Why hyaluronan is essential to healthy joints the horse. Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of streptococcus spp.
Hyaluronate, synvisc, synviscone, supartz, synojoynt, triluron, trivisc, visco3 are hyaluronan derivatives that are injected into the knee joints to increase the. For 30 years ha injections have been used to relieve pain and inflammation in equine and human joints. Hyalgan is a product based on a class of products known as hyaluronic acid, sodium hyaluronate, or hyaluronans. Obstruction of aqueous outflow by sodium hyaluronate in enucleated human eyes. Supartz sodium hyaluronate for the treatment of knee. Hyaluronate sodium injection route precautions mayo clinic. Intraarticular injection, sodium hyaluronate gel, sodium hyaluronate injection manufacturer supplier in china, offering ce sodium hyaluronate gel for intraarticular injection, nose lip crosslinked dermal filler injectable hyaluronic acid price, 2020 crosslinked sodium hyaluronate gel filler for breast enhancement and so on. It is a glycosaminoglycan and longchain polymer of disaccharide units of naglucuronatenacetylglucosamine. Safety of repeated injections of sodium hyaluronate. Everyday i get up ok but by lunch it hurts some by evening it gets worse and then last night april 16,2020 was the the worst ever. Sodium hyaluronate is used to treat knee pain caused by osteoarthritis. They received three weekly intraarticular injections of sodium hyaluronate 2 % and chondroitin sulfate 2 % in combination.
Hyaluronic acid intraarticular injections request form blue cross. Sodium hyaluronate of defined molecular size for treating osteoarthritis dhimant p. Supartz sodium hyaluronate is injected into the knee joint as a series of five injections. Bladder instillation of cystistat sodium hyaluronate. Amvisc, hyalgan sodium hyaluronate dosing, indications. Orthovisc 30 mg2 ml injection 4 8 180 sodium hyaluronate 20 mg2 ml injection 3 6 180 supartz 25 mg2. Beginning with services to be provided on and after january 1, 2018, the following drugs will be included as part of our medical injectables program mip. Hyaluronan injections sideeffects, uses, time to work. These are not all of the side effects that may occur.
Hyaluronic acids are used as viscosupplementation and are injected directly into the. Ghosh department of biotechnology, cadila pharmaceuticals ltd, 342 nani kadi, kadi 382 715, india sodium hyaluronate has been widely used in the treatment of osteoarthritis of the knee. Read the patient information leaflet provided by your health care professional before you start using hyaluronate and. The procedure involves an arthrocentesis to aspirate the damaged synovial fluid or joint effusion if present from the knee as directed by product.
X listed any eu regulation not listed above is not applicable to this product. Most people get the injections once a week for 2 to 5 weeks in a row, depending on which medication your doctor is using. Hyaluronic acid, primarily obtained from bacterial fermentation and rooster combs, does penetrate to the dermis. Legend injectable solution is pyrogen free, sterile and does not contain a preservative.
Just a single course of treatment five injections given weekly can provide longlasting pain relief. The efficacy study of sodium hyaluronate to treat symptomatic. China ce sodium hyaluronate gel for intraarticular injection. Full text the effect of sodium hyaluronatechondroitin. Swelling where gelone hyaluronate and derivatives injection knee is used.
Hyalgan is a viscous solution consisting of a high molecular weight 500,000730,000 daltons fraction of purified natural sodium hyaluronate hyalectin in buffered physiological sodium chloride, having a ph of 6. Healon r is a 1% solution of highly purified sodium hyaluronate from rooster combs. Viscoelastic solution for injection into the joint cavity. Cystistat is a solution containing 40mg of sodium hyaluronate in a 50ml vial, used to treat bladder conditions such as interstitial cystitis inflammation of bladder lining. Sodium hyaluronate an overview sciencedirect topics. For more information about your injection, ask your nurse for the resource hyaluronate and derivatives. The difference between hyaluronic acid and sodium hyaluronate. High molecular weight hyaluronan orthovisc, high molecular weight. Sodium hyaluronate ha protects the corneal endothelium during cataract surgery. Dailymed legend hyaluronate sodium injection, solution. Any sodium hyaluronate product is to be approved contingent on the coverage criteria in the diagnosisspecific criteria section.
Womac subscore a was assessed at 1, 3 and 6 months after the last injection. This transmission contains confidential information belonging to the sender that is legally privileged. Pharmaceutical sodium hyaluronate manufacturer contipro. The two names hyaluronic acid and sodium hyaluronate are used interchangeably in the beauty industry, but they do have their differences. Bladder instillation of cystistat sodium hyaluronate what is cystistat. Get sodium hyaluronate at best price with product specifications. Lupin has entered into the orthopaedic segment in india with launch of hyalgan sodium hyaluronate, a therapy against degenerative joint diseaseosteoarthritis. The healon ovd contains 10 mgml of sodium hyaluronate dissolved in physiological sodium chloride phosphate buffer ph 7. There is no difference in molecular weight between hyaluronic acid and sodium hyaluronate. Sodium hyaluronate injection update horizon blue cross.
Clinical policy effective 09012012 19962012, oxford health plans, llc 4 iv. The idea of hyaluronate injections comes from the direct understanding that oa derives from excessive mechanical stress applying to osteochondral surfaces 1. Sodium hyaluronate acts as a lubricant on the skin by restoring moisture and preventing friction or abrasion. A treatment course or cycle of supartz consists of 3 to 5 injections for a total dose of 75 to 125 mg of sodium hyaluronate.
Hope, hype, and hard truths, published in the february issue of the archives. A viscous, gellike material used in ophthalmic surgery to protect the important inner lining of the cornea and maintain the front chamber of the opened eye. Diagnosisspecific criteria initial authorization sodium hyaluronate naive patients intraarticular injections of sodium hyaluronate are proven and medically necessary when all of the following are met. Osteoarthritis oa is the most common agerelated degenerative joint disease in the world. Mar 17, 2020 sodium hyaluronate is usually given when other arthritis medications have not been effective. Sodium hyaluronate is injected to reduce wrinkles on the face.
Fda labeling durolane 1 injection euflexxa 3 injections gel one 1 injection gelsyn3 3 injections. A wide variety of injection sodium hyaluronate options are available to you, such as grade standard, usage, and feature. I got the durolane injection on tuesday of april 14,2020 and when i was walking out of office after shot it felt good, but by time i got home it hurt some. Hyalgan is administered by your health care provider as an intraarticular injection into the knee joint. Healon sodium hyaluronate ophthalmic viscosurgical device.